Steven Johnson syndrome

8 topics across 7 chapters

Chapter 1

Overview and epidemiology (definition, incidence, risk factors)

Chapter 2

Etiology and pathophysiology (drug triggers, infections, immunology, genetic associations)

Chapter 3

Clinical presentation and diagnosis (cutaneous and mucosal findings, severity assessment, skin biopsy, scoring systems like SCORTEN)

Chapter 4

Differential diagnosis (toxic epidermal necrolysis, erythema multiforme, staphylococcal scalded skin syndrome, drug rashes)

Chapter 5

Acute management and supportive care (ICU/burn unit care, wound care, fluid/electrolyte/nutrition, infection prevention)

Chapter 6

Specific treatments and controversies (systemic steroids, IVIG, cyclosporine, TNF inhibitors, evidence summary)

Chapter 7

Complications, prognosis, long-term follow-up and prevention (ocular/skin sequelae, rehabilitation, drug avoidance and pharmacogenetic screening)